Hydroxychloroquine induced hyperpigmentation



Purpose: Hydroxychloroquine (HCQ) is a systemic antimalarial used to treat cutaneous and systemic lupus erythematosus and other connective tissue diseases. (Photo: Melvin Chiu, M.D.). Hydroxychloroquine at a dose of 200 mg twice per day was administered 8 years previously for cutaneous lupus erythematosus Drug-Induced Hyperpigmentation caused by Plaquenil (Hydroxychloroquine) Plaquenil (Hydroxycholoroquine) Side Effects. It is a hydroxylated version of chloroquine, with a similar mechanism of action. OBJECTIVE: The aim of this study was to describe 4 patients with oral mucosa hyperpigmentation associated with 4 drug classes and to review the relevant literature. Cited by: 31 Publish Year: 2013 Author: Moez Jallouli, Camille Francès, Jean-Charles Piette, Du Le Thi Huong, Philippe Moguelet, Cecile Fact Drug-induced hyperpigmentation | DermNet NZ https://www.dermnetnz.org/topics/drug-induced-hyperpigmentation Drug-induced skin hydroxychloroquine induced hyperpigmentation pigmentation accounts for 10–20% of all cases of acquired hyperpigmentation. 2012 Oct;39(10):859-60. The staining pattern of hydroxychloroquine-induced hyperpigmentation of the dermis varies in different case reports. About 30% of women using oral estrogen report having melasma like facial pigmentation.Treatment of hormone-induced melasma works best after breastfeeding has stopped, a woman is no longer pregnant, or her contraceptives have changed. KIM. 3,9 Type 1 pigmentation is not correlated with treatment duration or cumulative dose, while type 2 and 3 are associated with long-term therapy. Eun B. Hydroxychloroquine-induced hyperpigmentation. Hydroxychloroquine-induced hyperpigmentation in systemic diseases: prevalence, clinical features and risk factors: a cross-sectional study of 41 cases E Bahloul1, M Jallouli1, S Garbaa1, S Marzouk1, A Masmoudi2, H Turki2 and Z Bahloul1. demonstrated that hydroxychloroquine-induced pigmentation is not rare. Discussion Hydroxychloroquine, which has a 4-aminoquinoline nucleus, is used in the management of malaria, rheumatologic disorders, and dermatologic conditions, such as lupus erythematosus, …. Cited by: 31 Publish Year: 2013 Author: Moez Jallouli, Camille Francès, Jean-Charles Piette, Du Le Thi Huong, Philippe Moguelet, Cecile Fact Hydroxychloroquine-induced pigmentation in patients with https://www.ncbi.nlm.nih.gov/pubmed/23824340 Hydroxychloroquine-induced pigmentation in patients with systemic lupus erythematosus: a case-control study. Dermatologic side effects have included mucocutaneous hyperpigmentation, nonlight-sensitive psoriasis, bleaching of hair, alopecia, pruritus, photosensitivity, and skin eruptions such as urticarial, morbilliform, lichenoid, maculopapular, …. Besides the familiar adverse reactions, a localized mucocutaneous bluish‐grey to black discolouration can sometimes be seen with antimalarial drugs Hydroxychloroquine-induced Hyperpigmentation of the Skin. JAMA Dermatol 2013; 149:935. Other rare side effects include changes in skin pigmentation and cardiomyopathy (diseases of the heart muscle) Jallouli M, Francès C, Piette JC, et al. Oral mucosal hyperpigmentation is a characteristic clinical feature which distinguishes it from chrysiasis the lesion confirmed the diagnosis of drug-induced oral pigmentation caused by chloroquine diphosphate. Jallouli M(1), Francès C, Piette JC, Huong du LT, Moguelet P, Factor C, Zahr N, Miyara M, Saadoun D, Mathian A, Haroche J, De Gennes C, Leroux G, Chapelon C, Wechsler B, Cacoub P, Amoura Z, Costedoat-Chalumeau N; Plaquenil LUpus Systemic Study Group. Hydroxychloroquine (Plaquenil®) is a 4-amino-quinoline antimalarial medication that is widely used to treat systemic lupus erythematosus (SLE), rheumatoid arthritis, and related inflammatory and dermatological conditions. Mucocutaneous hyperpigmentation is a well-documented side effect of HCQ that occurs in 10-25% of users. B, Optical coherence tomography image showing loss of photoreceptor layer (arrow; also known as ellipsoid zone loss) Abstract. A 32-year-old woman presented with a 1.5-year history of symmetric polyarthritis, positive rheumatoid factor, and anticyclic citrullinated peptide antibody, without erosive joint changes Jan 01, 2015 · Hydroxychloroquine (HCQ)-associated hyperpigmentation is uncommon, with onset ranging from 3 months to 22 years following the initiation of hydroxychloroquine induced hyperpigmentation therapy1. Mesinkovska MD PhD Ajay N. Hydroxychloroquine-induced retinopathy. Chloroquine (Hydroxychloroquine)-induced cardiomyopathy is a rare but potentially life-threatening condition. Kim, Eun J. Terbinafine-Induced Relapse of Bullous Lupus Erythematosus Subacute Cutaneous Lupus Erythematosus in a Male Patient on Multiple Antiepileptics Unmasked by Melatonin Eltrombopag: Efficacy and Safety in Steroid Refractory Lupus-Associated Immune Thrombocytopenia. Nov 11, 2008 · Besides the familiar adverse reactions, a localized mucocutaneous bluish‐grey to black discolouration can sometimes be seen with antimalarial drugs.