Chloroquine autophagy cancer



Treatment of rheumatoid arthritis and other autoimmune diseases Specifically, in cancer, autophagy plays a dichotomous role by inhibiting tumor initiation but supporting tumor progression. Whereas chloroquine impairs autophagy and proliferation in tumor cells, Maes et al. Thus, the role of autophagy in cancer is determined by nutrient availability, microenvironment stress, and the presence of an immune system Some reports have shown the potential relationship between autophagy and senescence in cancer cells exposed to chemotherapeutics agents (e.g., doxorubicin and camptothecin), and in nonmalignant cells exposed to pentacyclic triterpenoid betulinic acid Aug 27, 2018 · Up until recently, inhibition of the late stage of autophagy was thought to be the major mechanism of chloroquine-mediated cancer cells death. Common mechanisms of evasion include impaired antigen presentation caused by …. Mulcahy Levy, Andrew Thorburn Chloroquine & Hydroxychloroquine: supporting chemo https://www.cancertreatmentsresearch.com/chloroquine-hydroxychloroquine Nov 15, 2015 · However, note that Chloroquine has other properties as well that may be very well related to anti cancer mechanism, such as zinc ionophore, and others (see below the section on mechanisms). In cancer, autophagy can be neutral, tumor-suppressive, or tumor-promoting in different contexts. Common mechanisms of evasion include impaired antigen presentation caused by …. Mulloy a, b, Ashish Kumar , and Yi Zheng, aDivision of Experimental Hematology and Cancer Biology, …. autophagy as a therapeutic target and led to multiple early phase clinical trials in humans to evaluate autophagy inhibition using hydroxychloroquine in combination with chemotherapy or targeted agents. chloroquine; The core. Early results from clinical trials that repurposed hydroxychloroquine for cancer have suggested that autophagy inhibition may be a promising approach for advanced cancers. Also a number of small molecules reported to induce autophagy by targeting mammalian target of rapamycin (e.g., rapamycin analogs) or adenosine 5’-monophosphate-. mTOR signaling is often hyperactive in many tumors and can drive proliferation, so mTOR inhibitors are being investigated as anticancer agents TRANSLATIONAL RESEARCH PAPER Autophagy is dispensable for Kmt2a/Mll-Mllt3/Af9 AML maintenance and anti-leukemic effect of chloroquine Xiaoyi Chen a,b, Jason Clark , Mark Wunderlich , Cuiqing Fan a,c, Ashley Davis , Song Chenb, Jun-Lin Guanb, James C. Idalia Cruz , Alan Zwart1, and Robert Clarke1 Abstract. Cook 1, Anni W€arri , David R. However, recent research provided compelling evidence that autophagy-inhibiting activities of chloroquine are dispensable for its ability to suppress tumor cells growth.. Autophagy is a conserved process required for the degradation and recycling of damaged organelles and proteins Efficacy of autophagy inhibition with HCQ and chloroquine (CQ) has begun to be assessed in animal models and human cancer cells and lines, and the results are encouraging. Chloroquine (CQ) has been evaluated as an autophagy blocker for cancer treatment, but it is unknown if it acts solely by inhibiting cancer cell autophagy. Because chloroquine is a potent autophagy inhibitor that is FDA-approved and available for rapid translation to pedi-atric clinical trials, we evaluated its effects on our CNS tumor cells Mar 02, 2020 · For instance, a recent 2019 study surveys existing research into autophagy and cancer. chloroquine autophagy cancer Cancer cells need to acquire specific molecular traits in order to spread to distant organs. S2B). Ferrarelli Chloroquine enhances the cytotoxicity of topotecan by https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012269 Chloroquine enhances the cytotoxicity of topotecan by inhibiting autophagy in lung cancer cells Cited by: 30 Publish Year: 2011 Author: Yao Wang, Rui Qing Peng, Dan Dan Li, Ya Ding, Xiao Qi Wu, Yi Xin Zeng, Xiao Feng Zhu, Xiao Shi Zhang Autophagy in cancer: moving from understanding mechanism https://www.nature.com/articles/s41418-019-0474-7 Dec 13, 2019 · Autophagy has also been intricately linked to apoptosis and programmed cell death, and understanding these interactions is becoming increasingly important in improving cancer therapy and patient Cited by: 2 Publish Year: 2020 Author: Jean M. In our previous study, FIP-gts, an imm….Dec 01, 2016 · Chloroquine, a lysosomal inhibitor, is used for malaria, rheumatoid arthritis, and lupus erythematosus therapy. However, it has recently been suggested that chloroquine may also function as an inhibitor of CXCR4 signaling ( 16 ) Inhibition of autophagy using chloroquine (CQ) together with LUT treatment in MET4 cells decreased viability significantly more than addition of LUT alone. In this view, chloroquine, a 4-alkylamino substituted quinoline family member, is an autophagy inhibitor that blocks the fusion of autophagosomes and lysosomes. Nevertheless, the role of autophagy in cancer is somewhat controversial In particular, the autophagy inhibitors chloroquine and hydroxychloroquine, commonly used antimalarial drugs, are currently being investigated in phase I and phase II trials in patients with glioblastoma and myeloma. 1D ) and a resultant high degree of autophagy inhibition (Supplementary Fig. SBI-0206965 was shown to suppress autophagy induced by mTOR inhibition. In our previous study, FIP-gts, an imm…. This is why authophagy can be both good and bad.. Chloroquine (CQ) has been evaluated as an autophagy blocker for cancer treatment, but it is unknown if it acts solely by inhibiting cancer cell autophagy. LC3-II is used as a quantitative marker of autophagy since it is required for the formation of the autophagosome and its level is proportional to the amount of autophagosomes in the cell , , .To determine concentrations of bafilomycin and chloroquine …. Cells use autophagy as a kind of recycling to “eat” unneeded materials, often to provide. 38 From the perspective of the whole autophagy process, BP nanosheets retard. Among them, CQ was found especially effective in cancer treatment in combination of anti-cancer drugs such as cisplatin [30] Targeting autophagy with small molecules for cancer therapy Sree Karani Kondapuram 1, chloroquine, etc.) are reported in pre-clinical and clinical study. In the present study, we evaluated the effects of everolimus alone or in combination with chloroquine on renal cancer cell viability and verified possible synergism Breast cancer (BC) is a potentially life-threatening malignant tumor that still causes high mortality among women. On the other hand, the very effect of chloroquine to inhibit autophagy could also sensitize kidney cells … Cited by: 401 Publish Year: 2013 Author: Tomonori Kimura, Yoshitsugu Takabatake, Atsushi Takahashi, Yoshitaka Isaka Chloroquine in cancer therapy: a double-edged sword of https://www.ncbi.nlm.nih.gov/pubmed/23288916 Jan 01, 2013 · Autophagy is a homeostatic cellular chloroquine autophagy cancer recycling system that is responsible for degrading damaged or unnecessary cellular organelles and proteins.