Chloroquine In Cancer Therapy A Double-edged Sword Of Autophagy



6 In other studies, treatment of various cancer cells with small-molecule autophagy inhibitors, such as 3-methyladenine. Autophagy is believed to be a double-edged sword during viral infection ( Choi et al., 2018). In this view, chloroquine, a 4-alkylamino substituted quinoline family member, is an autophagy inhibitor that blocks the fusion of autophagosomes and lysosomes. Chloroquine (CQ), an antimalarial agent, is able to induce sustained endoplasmic reticulum (ER) stress by functioning as an autophagy inhibitor However, autophagy has been referred to as a double-edged sword because in certain cellular contexts, excessive or sustained tumor cell autophagy may be prodeath, particularly in apoptosis-defective cells . Dissecting pharmacological effects of chloroquine in cancer treatment: interference with inflammatory signaling pathways. Chloroquine in cancer therapy: a double-edged sword of autophagy. Chloroquine is reported to inhibit autophagy and cell proliferation. On one hand, autophagy plays an antitumor role, on the other hand. 2 and then switched to MAS buffer before permeabilization with PMP and chloroquine in cancer therapy a double-edged sword of autophagy OCR …. Autophagy plays a crucial role in cancer cell survival and the inhibition of autophagy is attracting attention as an emerging strategy for the treatment of cancer. Author information: (1)Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan. The role of autophagy in cancer is complex. Chloroquine in cancer therapy: a double-edged sword. May 25, 2014 · Abstract. Chloroquine is a 4-aminoquinoline that is commonly used as an antimalarial agent. in cancer therapy. Cancer Res 73: 3–7. However, blocking autophagy with chloroquine enhances the anticancer effect of sunitinib [24]. Autophagy, a key player in microenvironment maintenance, can be induced by many conditions, such as nutrient deprivation, oxidative stress, and drug treatment . Chloroquine enhances the efficacy of cisplatin by suppressing autophagy in human adrenocortical carcinoma treatment Liang Qin,1,* Tianyuan Xu,1,* Leilei Xia,1 Xianjin Wang,1 Xiang Zhang,1 Xiaohua Zhang,1 Zhaowei Zhu,1 Shan Zhong,1 Chuandong Wang,2 Zhoujun Shen1 1Department of Urology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 2Key Laboratory of Stem Cell …. Taken together, these results indicate that autophagy induction positively contributes to …. cancer metastasis, and the inhibition of autophagy might be an effective treatment strategy for malignant cancer [12]. a double-edged sword of autophagy. Although autophagy acts as a “double-edged sword” in tumorigenesis , autophagy acts more as a cytoprotective mechanism in tumor therapy .. Oct 01, 2014 · Chloroquine is an antimalarial drug that has been used in humans for many years . Figure 1. Chloroquine (CQ) is an anti-malarial drug, and is also known as an inhibitor of autophagy In renal cancer, sorafenib could induce autophagic cell death through Akt inhibition [23]. “Autophagy in health and disease: a double-edged sword. Jun 14, 2019 · Based on this knowledge, in vivo studies have started to employ autophagy inhibitors, such as inhibitors of the lysosomal protease and anti-malaric drugs, Chloroquine (CQ) or Hydroxichloroquine (HCQ), to treat cancer, more often in combination with chemotherapies able to induce autophagy [17,18,19] The double-edged sword function of autophagy, as both a tumor suppressor and a protector of cancer cell survival, likely impacts anticancer treatment efficacy in opposing ways. Abstract: Aside from its function in cellular homeostasis, autophagy enables cells to dispose of damaged cellular components and to recycle metabolites in response to cellular stress.. Mice with neuron-specific knock out of the core autophagy protein, ATG7, are viable but most go on to develop behavioral defects and eventually massive neuronal loss in the cerebral corticies 1 Apr 14, 2016 · Autophagy in dental tissues: a double-edged sword and during local anesthetic treatment. The affected tooth cells can be of epithelial or mesenchymal origin depending on ….Inhibition of KRAS, MEK, or ERK induces autophagic flux in KRAS-driven cancer cells via metabolic rewiring and activation of the AMPK–ULK1 pathway Autophagy plays a crucial role in cancer cell survival and the inhibition of autophagy is attracting attention as an emerging strategy chloroquine in cancer therapy a double-edged sword of autophagy for the treatment of cancer. In spite of this, inhibition of autophagy in the clinic can behave as a double-edged sword because it can enhance or suppress cancer immune response Unlike apoptosis, autophagy is considered a double-edged sword that depends on the nature and cellular context of the stimuli 16,17. Accordingly, autophagy becomes a potential target for. chloroquine reduces autophagy at a relatively late stage.7,11,21,22 Autophagy can be induced by several conditions, including anticancer agents (Table I), and is regulated by a number of protein kinases, the best characterised being the mammalian target of rapamycin …. Article Sections. Therefore, this review tries to fill this gap. However, autophagy may be a double-edged sword with conflicting and competing tumor cell-intrinsic and -extrinsic effects that can inhibit and promote tumor initiation, promotion, progression, and metastasis Regulation of Autophagy by Short Chain Fatty Acids in Colon Cancer Cells, Autophagy - A Double-Edged Sword - Cell Survival or Death?, Yannick Bailly, IntechOpen, DOI: 10.5772/54999.